EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America.

EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America.

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INTRODUCTION:Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography.Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding.METHODS:Observational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region.Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired.De-identified clinical and lab data were entered in a specifically designed on-line platform.

Co-variables potentially linked to AKI Tea Light Holder onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model.RESULTS:Fifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage.Median age 64 (50-74) yrs; most of them were male (61%) and mestizos (42%).Comorbidities were present in 77%.AKI was community-acquired in 62%.

Dehydration, shock and nephrotoxic drugs were the commonest causes.During their process of care, 77% of patients were assessed by nephrologists.Kidney replacement therapy (KRT) was performed in 29% of cases.In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation.

At 90-days follow up partial RHODIOLA ROSEA or complete renal recovery was 81% and mortality 24%.CONCLUSIONS:AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs.Mortality was high and long-term follow up poor.Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.